4-1 Publications Internationales

ANNEE 2020

Sellam LS, Zappasodi R, Chettibi F, Djennaoui D, Yahi-Ait Mesbah N, Amir-Tidadini ZC, Touil-Boukoffa C, Ouahioune W, Merghoub T, Bourouba M(2020).Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism.Arch Biochem Biophys.2020 Sep 15;690:108479. doi: 10.1016/j.abb.2020.108479. Epub 2020.


International consensus on terminology to be used in the field of echinococcoses.Vuitton DA, McManus DP, Rogan MT, Romig T, Gottstein B, Naidich A, Tuxun T, Wen H, Menezes da Silva A; World Association of Echinococcosis(Amri M,BenazzouzS, Labsi M,Soufli I, Touil-Boukoffa)Parasite. 2020;27:41. doi: 10.1051/parasite/2020024. Epub 2020 Jun 3.


Douaoui S, Djidjik R, Boubakeur M, Ghernaout M, Touil-Boukoffa C, Oumouna M, Derrar F, Amrani (2020).GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function.Immunobiology. 2020 May;225(3):151950. doi: 10.1016/j.imbio.2020.151950. Epub 2020 May 1.


Bouchemal M, Hakem D, Azzouz M, Touil-Boukoffa C, Mezioug (2020)Vitamin D Levels Correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immunomodulatory Effect of α, 25 Dihydroxyvitamin D.Endocr Metab Immune Disord Drug Targets. 2020;20(8):1282-1294.doi:10.2174/1871530320666200402121917.


Djaballah-Ider F, Touil-Boukoffa C(2020).Effect of combined colchicine-corticosteroid treatment on neutrophil/lymphocyte ratio: a predictive marker in Behçet disease activity.Djaballah-Ider F, Touil-Boukoffa C.Inflammopharmacology. 2020 Aug;28(4):819-829. doi: 10.1007/s10787-020-00701-x. Epub 2020 Mar 29.


Chekaoui A, Belguendouz H, Lahmar K, Mazari F, Terahi M, Hakem D, Youinou P, Touil-Boukoffa(2020). Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet’s disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.Int Immunopharmacol. 2020 Mar;80:106119. doi: 10.1016/j.intimp.2019.106119. Epub 2020 Jan 9.


Tilioua S, Mezioug D, Amir-Tidadini ZC, Medjdoub YM, Touil-Boukoffa C (2020)Potential role of NF-κB pathway in the immuno-inflammatory responses during human cystic echinococcosis.Acta Trop. 2020 Mar;203:105306. doi: 10.1016/j.actatropica.2019.105306.


Galleze A, Kocyigit A, Cherif N, Attal N, Touil-Boukoffa C, Raache R(2020). Assessment of oxidative/anti-oxidative markers and DNA damage profile induced by chemotherapy in algerian children with lymphoma..Drug Chem Toxicol. 2020 Mar;43(2):169-173. doi: 10.1080/01480545.2019.1659309. Epub 2019 Aug 29

ANNEE 2019

Kariche N, Moulaï N, Sellam LS, Benyahia S, Ouahioune W, Djennaoui D, Touil-Boukoffa C, Bourouba M. Expression Analysis of the Mediators of Epithelial to Mesenchymal Transition and Early Risk Assessment of Therapeutic Failure in Laryngeal Carcinoma. J Oncol. 2019 Dec 6;2019:5649846. doi: 10.1155/2019/5649846. eCollection 2019.


Labsi M, Soufli I, Khelifi L, Amir ZC, Touil-Boukoffa C(2019).A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach.Acta Trop. 2019 Sep;197:105050. doi: 10.1016/j.actatropica.2019.105050. Epub 2019 Jun 4.


Mihoubi E, Raache R, Amroun H, Azzouz M, Galleze A, Zaabat N, Aissou A, Ferhat A, Guettaf-Sadi H, Boutemeur A, Aoudia Z, Boudiba A, Touil-Boukoffa C, Abbadi MC, Attal N (2019).Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population..Endocr Metab Immune Disord Drug Targets. 2019;19(8):1172-1176. doi: 10.2174/1871530319666190529113404.


Meziane W, Mekkaoui Z, Hai I, Kacimi K, Djilali K, Touil-Boukoffa C, Lefranc G, Fernandez A, Lamb N, Mennechet F, Aribi M (2029)..Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages.Int Immunopharmacol. 2019 Aug;73:212-224. doi: 10.1016/j.intimp.2019.05.004. Epub 2019 May 17.


F.BouldjennetaA.HirechecN.Kechoutd1S.BouazizTerrachetb1M.Azzouze1E.Mihoubia1A.AissoudC.Touil-BoukoffaaN.AttaldR.Raache. (2019).Clinical characteristics of Algerian subjects with MODY p.R85W glucokinase mutation- in silico assessment of p.R85W effect on glucokinase structure and function. Meta Gene (19) :268-275 .https://doi.org/10.1016/j.mgene.2018.12.013.


Nahla DeghbarDalila MeziougTouri KahinaYacine-Miloud MedjdoubChafia Touil- Boukoffa(2019). Antihydatic and immunomodulatory effects of Algerian propolis ethanolic extract: In vitro and in vivo study.Asian Pacific Journal of Tropical Medicine  2019 -12 (3 ):106-116. https://www.apjtm.org/text.asp.2019/12/3/106/254936.


Belkhelfa M*, Beder N, Rafa H, Touil-Boukoffa C (2019).The Pivotal Role of Neuroinflammation in the Genesis and Evolution of Alzheimer’s Disease Alzheimer’s Disease & Treatment Book, Chapter 6 .


H Rafa, SBenkhelifa  N Delhem, C Touil-Boukoffa. (20219). Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers European Journal of Immunology (49)171-171 …, 2019 – ST, HOBOKEN 07030-5774, NJ USA.


S Benazzouz,M Amri,J Wang,B Gottstein A Ketfi, M Gharnaout, C Touil-Boukoffa . (2019). Echinococcus granulosus laminated layer: characterization of immunoregulatory activity and proteins composition; European Journal of Immunology (49)1267-1267…, 2019 – ST, HOBOKEN 07030-5774, NJ USA.


N Kariche,NMoulai,SBenyahi,W Ouahioune D, Djennaoui, C Touil-Boukoffa,M Bourouba (2019).Tumor associated macrophages (TAM) infiltration associate with IL-10 enriched microenvironments and epithelial-mesenchymal transition in invasive. European Journal of Immunology (49)219-220 – ST, HOBOKEN 07030-5774, NJ USA.


S Benazzouz ,MAmri,A Ketfi,M Gharnaout, C Touil-Boukoffa . (2019). Evaluation of systemic production of nitric oxide and metalloproteinase-9 in algerian patients with allergic asthma during stable and exacerbation status.ALLERGY 74,782-782.


S Benazzouz ,MAmri,A Ketfi,M Gharnaout, C Touil-Boukoffa .(2019). Age and obesity are associated with increased asthma severity in algerian patients with allergic asthmaALLERGY 74,723-723.


Mihoubi E, Bouldjennet F, Raache R, Amroun H, Azzouz M, Benazouz N, Touil-Boukoffa C, Attal N. T-786C endothelial nitric oxide gene polymorphism and type 1 diabetic retinopathy in the Algerian population. J Fr Ophtalmol. 2019 Apr 5. pii : S0181-5512(19)30118-4. doi : 10.1016/j.jfo.2018.11.014. [Epub ahead of print] French.


Mihoubi E, Amroun H, Raache R, Bouldjennet F, Meçabih F, Azzouz M, Boudiba A, Mahgoun S, Akachouche M, Salhi N, Touil-Boukoffa C, Abbadi MC, Attal N. Human Leukocyte Antigens (HLA) Genes Association in Type 1 Diabetic Nephropathy. Endocr Metab Immune Disord Drug Targets. 2019 Feb 15. doi : 10.2174/1871530319666190215143059.


Djaballah-Ider F, Djaballah A, Djeraba Z, Chaib S, Touil-Boukoffa C. Auto-immunity profile evaluation during different clinical manifestations of Behçet disease in Algerian patients : effect of corticosteroid treatment. Inflammopharmacology. 2019 Feb 5. doi : 10.1007/s10787-019-00567-8.


Benkhelifa S1, Rafa H1,2, Belhadef S3, Ait-Kaci H4, Medjeber O1, Belkhelfa M1, Hetit S5, Ait-Younes S6, De Launoit Y2, Moralès O2, Mahfouf H3, Delhem N2, Touil-Boukoffa C7. Aberrant up-regulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer : immunomodulatory effects of cetuximab combined with chemotherapy. Send to Inflammopharmacology. 2019 Jan 24. doi : 10.1007/s10787-019-00566-9.

ANNEE 2018

Chekaoui A, Lahmar K, Belguendouz H, Mazari F, Terahi M, Hakem D, Youinou P, Touil-Boukoffa C. Increased IL-1β levels are associated with an imbalance of “oxidant/antioxidant” status during Behçet’s disease. Eur Cytokine Netw. 2018 Sep 1 ;29(3):95-102.


Eddaikraa,, H. Amroun, R. Raache, A. Galleze, N. Abdallah-Elhadjd, M. Azzouze, F. Meçabihc, B. Mechtic, M.C. Abbadic, C. Touil-Boukoffab, N. Attal. 2018 clinical variables and ethnicity may influenced by polymorphism of CAT −262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications A. Gene 182-192.


Benchabane S, Belkhelfa M, Belguendouz H, Zidi S, Boudjelida A, Youinou P, Touil-Boukoffa C. Interferon-β inhibits inflammatory responses mediators via suppression of iNOS signaling pathway in PBMCs from patients with primary Sjögren’s syndrome. Inflammopharmacology. 2018 Oct ;26(5):1165-1174. doi : 10.1007/s10787-018-0499-4. Epub 2018 Jun 4.


Boutemine IM, Amri M, Amir ZC, Fitting C, Mecherara-Idjeri S, Layaida K, Sennoun N, Berkane S, Cavaillon JM, Touil-Boukoffa C. Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats. J Ethnopharmacol. 2018 Oct 5 ;224:273-282. doi : 10.1016/j.jep.2018.05.040. Epub 2018 May 31.


Belkhelfa M, Beder N, Mouhoub D, Amri M, Hayet R, Tighilt N, Bakheti S, Laimouche S, Azzouz D, Belhadj R, Touil-Boukoffa C. The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia. J Neuroimmunol. 2018 Jul 15 ;320:48-57. doi : 10.1016/j.jneuroim.2018.04.004. Epub 2018 Apr 17.


Touri K, Belguendouz H, Medjeber O, Djeraba Z, Lahmar K, Touil-Boukoffa C. Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. Inflammopharmacology. 2018 May 11. doi : 10.1007/s10787-018-0487-8. [Epub ahead of print].


Djaballah-Ider F, Djeraba Z, Chemli M, Dammene-Debbihe N, Lounis D, Belguendouz H, Medour Y, Chaib S, Touil-Boukoffa C. Influence of corticosteroid therapy on IL-18 and nitric oxide production during Behçet’s disease. Inflammopharmacology. 2018 Mar 29. doi : 10.1007/s10787-018-0472-2. [Epub ahead of print].


Kariche N, Hortal MT, Benyahia S, Alemany L, Moulaï N, Clavero O, Muñoz M, Ouahioune W, Djennaoui D, Touil-Boukoffa C, de Sanjosé S, Bourouba M. Comparative assessment of HPV, alcohol and tobacco etiological fractions in Algerian patients with laryngeal squamous cell carcinoma. Infect Agent Cancer. 2018 Mar 13 ;13:8. doi : 10.1186/s13027-018-0181-x. eCollection 2018.


Medjeber O, Touri K, Rafa H, Djeraba Z, Belkhelfa M, Boutaleb AF, Arroul-Lammali A, Belguendouz H, Touil-Boukoffa C. Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease : involvement of nitric oxide pathway. Inflammopharmacology. 2018 Mar 7. doi : 10.1007/s10787-018-0460-6. [Epub ahead of print].


Labsi M, Soufli I, Khelifi L, Amir ZC, Touil-Boukoffa C. In vivo treatment with IL-17A attenuates hydatid cyst growth and liver fibrogenesis in an experimental model of echinococcosis. Acta Trop. 2018 May ;181:6-10. doi : 10.1016/j.actatropica.2018.01.014. Epub 2018 Feb 3.


Benchabane S, Belguendouz H, Behairi N, Arroul-Lammali A, Boudjelida A, Youinou P, Touil-Boukoffa C. Cardamonin inhibits pro-inflammatory cytokine production and suppresses NO pathway in PBMCs from patients with primary Sjögren’s syndrome. Immunopharmacol Immunotoxicol. 2018 Apr ;40(2):126-133. doi : 10.1080/08923973.2017.1418881. Epub 2018 Jan 5.

ANNEE 2017

R Raache, H Amroun , M Azzouz , E Mihoubi , A Boudiba, C Touil-Boukoffa , M C Abbadi , Nabila Attal. Gene polymorphisms of cytokines IFN +874 (A/T), TNF α -308 (G/A), IL-6 -174 (G/C), l’IL-10 -1082 (A/G), -819 (C/T) -592 (C/A), TGF-β1 +869 (T/C), +915 (G/C) in Algerian type 1 diabetes and latent autoimmune diabetes in adults (LADA). Journal of diabetes and obesity 2017 2(4) 145-165.


Galleze A, Raache R, Cherif N, Eddaïkra A, Belhani M, Bensenouci A, Touil-Boukoffa C, Abbadi M C, Attal N. Increased level of lactate dehydrogenase correlates with disease growth in Algerian children with lymphoma 2017
Journal of Hematology and Oncology Research 4(2):182-192.


Zidi S, Bediar-Boulaneb F, Belguendouz H, Belkhelfa M, Medjeber O, Laouar O, Henchiri C, Touil-Boukoffa C. Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium. Int J Immunopathol Pharmacol. 2017 Nov 1:394632017742505. doi : 10.1177/0394632017742505. [Epub ahead of print].


Djeraba Z, Benlabidi F, Djaballah-Ider FZ, Medjeber O, Arroul-Lammali A, Belguendouz H, Otmani F, Touil-Boukoffa C. Vitamin D status in Algerian Behçet’s disease patients : an immunomodulatory effect on NO pathway. Immunopharmacol Immunotoxicol. 2017 Aug ;39(4):243-250. doi : 10.1080/08923973.2017.1327967. Epub 2017 May 22.


Zeghir-Bouteldja R, Polomé A, Bousbata S, Touil-Boukoffa C. Comparative proteome profiling of hydatid fluid from Algerian patients reveals cyst location-related variation in Echinococcus granulosus. Acta Trop. 2017 Jul ;171:199-206. doi : 10.1016/j.actatropica.2017.03.034. Epub 2017 Apr 13.


Rafa H, Benkhelifa S, AitYounes S, Saoula H, Belhadef S, Belkhelfa M, Boukercha A, Toumi R, Soufli I, Moralès O, de Launoit Y, Mahfouf H, Nakmouche M, Delhem N, Touil-Boukoffa C. All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer. Mediators Inflamm. 2017 ;2017:7353252. doi : 10.1155/2017/7353252. Epub 2017 Mar 20.


Arroul-Lammali A, Rahal F, Chetouane R, Djeraba Z, Medjeber O, Ladjouze-Rezig A, Touil-Boukoffa C. Ex vivo all-trans retinoic acid modulates NO production and regulates IL-6 effect during rheumatoid arthritis : a study in Algerian patients. Immunopharmacol Immunotoxicol. 2017 Apr ;39(2):87-96. doi : 10.1080/08923973.2017.1285919. Epub 2017 Feb 10.

Khelifi L, Soufli I, Labsi M, Touil-Boukoffa C.Ummune-protective effect of echinococcosis on colitis experimental model is dependent of down regulation of TNF-α and NO production.Acta Trop. 2017 Feb ;166:7-15. doi : 10.1016/j.actatropica.2016.10.020.

ANNEE 2016

A Bouzidi, H Mesbah-Amroun, A Boukercha, F Benhassine, R Belboueb, K Berkouk, W Messadi, C Touil-Boukoffa. Association between MDR1 genepolymorphisms and the risk of Crohn’sdisease in a cohort of Algerian pediatric patients.PediatrRes. 2016 Dec ;80(6):837-843.Nature.Publishing.Group.


R Toumi, I Soufli, C Touil-boukoffa – CYTOKINE, 2016 – … SCIENCE LTD 24-28 OVAL RD, …LACTOBACILLUS AND BIFIDOBACTERIUM TREATMENT CONTRIBUTE TO AN IMMUNOREGULATORY PROFILE THROUGH UP REGULATION OF TGF-beta/FOXP3 IN EXPERIMENTAL COLITIS MODEL.


Soufli, Imene ; Toumi, Ryma ; Rafa, Hayet and Touil-Boukoffa,Chafia. Chapter In book : New Insights into Inflammatory Bowel Disease :Cytokines and Nitric Oxide in Immunopathogenesis of IBD and Potential Therapeutic Approaches Chapter (PDF Available) • October 2016  DOI : 10.5772/65001 .


Behairi N, Belkhelfa M, Rafa H, Labsi M, Deghbar N, Bouzid N, Mesbah-Amroun H, Touil-Boukoffa C. All-trans retinoic acid (ATRA) prevents lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment in aged rats. JNeuroimmunol. 2016 Nov 15 ;300:21-29.


Soufli I, Toumi R, Rafa H, Touil-Boukoffa C. Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther. 2016 Aug 6 ;7(3):353-60.


Amri M, Touil-Boukoffa C. In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pac J Trop Med. 2016 Aug ;9(8):749-56.


Dalila Mezioug ; Chafia Touil-Boukoffa. Increase IL-10 and TGF-beta levels in relapsing patients with hydatidosis : their involvement in the persistent infection control.Scandinavian Journal of Immunology. 83(5):385, May 2016.


Benchabane S, Boudjelida A, Toumi R, Belguendouz H, Youinou P, Touil-Boukoffa C. A case for IL-6, IL-17A, and nitric oxide in the pathophysiology of Sjögren’s syndrome. Int J Immunopathol Pharmacol. 2016 May 19.


Ahmedi ML, Belguendouz H, Messaoudene D, Mesbah-Amroun H, Terahi M, Lahlou-Boukoffa OS, Touil-Boukoffa C. Influence of steroid hormones on the production of two inflammatory markers, IL-12 and nitric oxide, in Behçet’s disease. J Fr Ophtalmol. 2016 Apr ;39(4):333-40.


Zergoun AA, Zebboudj A, Sellam SL, Kariche N, Djennaoui D, Ouraghi S, Kerboua E, Amir-Tidadini ZC, Chilla D, Asselah F, Touil-Boukoffa C, Merghoub T, Bourouba M. IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients. Tumour Biol. 2016 Mar ;37(3):3505-14.


Fagone P, Mangano K, Di Marco R, Touil-Boukoffa C, Chikovan T, Signorelli S, Lombardo GA, Patti F, Mammana S, Nicoletti F. J Neuroimmunol. Expression of DNA methylation genes in secondary progressive multiple sclerosis. 2016 Jan 15 ;290:66-9.


M. Labsi., L. Khelifa., D. Mezioug,I. Soufli.& C.Touil-Boukoffa.Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcose. Asian Pacific Journal of Tropical Medicine 2016 ; 9(3):2011-220.

ANNEE 2015

Galleze A, Raache R., Amroun H. Cherif N. , Fadli M., Meçabih F. , Belhani M., Bensenouci A., Abbadi M C. Attal N (2015) HLA polymorphism in Algerian children with lymphomas J Pediatr Hematol Oncol. 2015 Nov ; 37(8) : 458-61.


Zergoun AA, Zebboudj A, Sellam SL, Kariche N, Djennaoui D, Ouraghi S, Kerboua E, Amir-Tidadini ZC, Chilla D, Asselah F, Touil-Boukoffa C, Merghoub T, Bourouba M. IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients. Tumour Biol. 2015 Oct 9.


Behairi N, Belkhelfa M, Mesbah-Amroun H, Rafa H, Belarbi S, Tazir M, Touil-Boukoffa C. All- trans -Retinoic Acid Modulates Nitric Oxide and Interleukin-17A Production by Peripheral Blood Mononuclear Cells from Patients with Alzheimer’s Disease. Neuroimmunomodulation. 2015 Aug 8. Select item 261670782.


Boukercha A, Mesbah-Amroun H, Bouzidi A, Saoula H, Nakkemouche M, Roy M, Hugot JP, Touil-Boukoffa C. NOD2/CARD15 gene mutations in North Algerian patients with inflammatory bowel disease. World J Gastroenterol. 2015 Jul 7 ;21(25):7786-94. doi : 10.3748/wjg.v21.i25.7786. PMID : 26167078.


Amri M, Touil-Boukoffa C. A protective effect of the laminated layer on Echinococcus granulosus survival dependent on upregulation of host arginase. Acta Trop. 2015 Sep ;149:186-94. doi : 10.1016/j.actatropica.2015.05.027. Epub 2015 Jun 3.


Belguendouz H, Messaoudene D, Lahmar-Belguendouz K, Djeraba Z, Otmani F, Terahi M, Tiar M, Hartani D, Lahlou-Boukoffa OS, Touil-Boukoffa C.. In vivo and in vitro IL-18 production during uveitis associated with Behçet disease : effect of glucocorticoid therapy. J Fr Ophtalmol. 2015 Mar ;38(3):206-12. doi : 10.1016/j.jfo.2014.10.005.


Bourouba M, Zergoun AA, Maffei JS, Chila D, Djennaoui D, Asselah F, Amir-Tidadini ZC, Touil-Boukoffa C, Zaman MH. TNFα antagonization alters NOS2 dependent nasopharyngeal carcinoma tumor growth. Cytokine. 2015 Apr 23. pii : S1043-4666(15)00143-X. doi : 10.1016/j.cyto.2015.04.003.


Manel Amri, Merzak Gharnaout, Chafia Touil-Boukoffa. Systemic production of nitric oxide during severe asthma : immonumodulation by the helminth echinococcus granulosus Clin Transl Allergy. 2015 ; 5(Suppl 2) : P17. Published online 2015 March 23. doi : 10.1186/2045-7022-5-S2-P17.


Imene Soufli, Ryma Toumi, Hayet Rafa, Manel Amri, Moussa Labsi, Lila Khelifi, Ferdinando Nicoletti, Chafia Touil-Boukoffa. Crude extract of hydatid laminated layer from Echinococcus granulosus cyst attenuates mucosal intestinal damage and inflammatory responses in Dextran Sulfate Sodium induced colitis in mice J Inflamm (Lond) 2015 ; 12 : 19. Published online 2015 March 17. doi : 10.1186/s12950-015-0063-6.


Houda Belguendouz, Karima Lahmar-Belguendouz, Djamel Messaoudene, Zineb Djeraba, Fifi Otmani, Djennat Hakem, Ouided S. Lahlou-Boukoffa, Pierre Youinou, Chafia Touil-Boukoffa. Cytokines Modulate the “Immune-Metabolism” Interactions during Behçet Disease : Effect on Arginine Metabolism. Int J Inflam. 2015 ; 2015 : 241738. Published online 2015 January 27. doi : 10.1155/2015/241738.


IL-17A correlates with the nitric oxide pathway in immune host response during human cystic echinococcosis. D Mezioug, C Touil-Boukoffa. Cytokine 76 (1), 85.


Inhibition of the TNF-a/NOS2 inflammatory pathway alters nasopharyngeal carcinoma tumor growth. M Bourouba, AA Zergoun, J Maffei, SL Sellam, S Ouraghi, D Djennaoui, … Cytokine 76 (1), 68.


APRIL increase is related to Antibodies production and clinical manifestations during Behçet disease : A study in Algerian patients. H Belguendouz, S Chaib, K Lahmar-Belguendouz, D Messaoudene, … Cytokine 76 (1), 73.


IL-17A and Nitric Oxide production are involved in primary Pterygium pathogenesis : A study in Algerian patients. S Zidi, F Boulaneb-Bediar, M Belkhelfa, H Belguendouz, O Medjeber, …Cytokine 76 (1), 68-69.


Hydatid laminated layer from cestode helminth E. granulosus reduces severity in mice colitis through IFNγ, TNFα downregulation and IL10 upregulation I Soufli, R Toumi, H Rafa, M Amri, C Touil-Boukoffa. Cytokine 76 (1), 66.

ANNEE 2014

Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis. Toumi R, Abdelouhab K, Rafa H, Soufli I, Raissi-Kerboua D, Djeraba Z, Touil-Boukoffa C. Immunopharmacol Immunotoxicol. 2013 Jun ;35(3):403-9. doi : 10.3109/08923973.2013.790413.


Zebboudj A, Maroui MA, Dutrieux J, Touil-Boukoffa C, Bourouba M, Chelbi-Alix MK, Nisole S.Sodium arsenite induces apoptosis and Epstein-Barr virus reactivation in lymphoblastoid cells.Biochimie. 2014 Dec ;107 Pt B:247-56. Doi.


Hayet Rafa, Mourad Belkhelfa, Houria Saoula, Yvan de Launoit, M’hamed Nakmouche, Nadira Delhem, Chafia Touil-Boukoffa involvement of Th2 (interleukin-4) and Tumor necrosis factor-alpha in bowel disease pathogenesis through CD23/ no pathway : immunomodulatory effect of retinoic acid Clin Transl Allergy. 2014 ; 4(Suppl 2) : P60. Published online 2014 March 17. doi : 10.1186/2045-7022-4-S2-P60.


H. Mesbah-Amroun, A. Boukercha, A. Bouzidi, R. Hannachi, S. Lamani, C. Touil-Boukoffa.Analyse de la fréquence du variant allelique C1858T du gène PTPN22 dans une cohorte de la population algérienne.Diabetes & Metabolism, Volume 40, Supplement 1, March 2014.


Manel Amri, Chafia Touil-Boukoffa ; Induction of Treg and alternatively activated macrophages by the helminth Echinococcus granulosus : implication in the promotion or control of allergic disease ?Clin Transl Allergy. 2014 ; 4(Suppl 2) : P61. Published online 2014 March 17. doi : 10.1186/2045-7022-4-S2-P61.


Belkhelfa M, Rafa H, Medjeber O, Arroul-Lammali A, Behairi N, Abada-Bendib M, Makrelouf M, Belarbi S, Masmoudi AN, Tazir M, Touil-Boukoffa C..IFN-γ and TNF-α Are Involved During Alzheimer Disease Progression and Correlate with Nitric Oxide Production : A Study in Algerian Patients.J Interferon Cytokine Res. 2014 May 15. [Epub ahead of print].


Djeraba Z, Boumedine K, Arroul-Lammali A, Otmani F, Belguendouz H, Touil-Boukoffa C.Ex vivo immunomodulatory effect of all-trans-retinoic acid during Behçet’s disease : a study in Algerian patients.Immunopharmacol Immunotoxicol. 2014 Feb ;36(1):78-86. doi : 10.3109/08923973.2013.873048. Epub 2013 Dec 26.

ANNEE 2013

Fagone P, Patti F, Mangano K, Mammana S, Coco M, Touil-Boukoffa C, Chikovani T, Di Marco R, Nicoletti F.( 2013) ;Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis. Journal of Neuroimmunology 2013 May 25. doi:pii : S0165-5728(13)00097-0. 10.1016/j.jneuroim.2013.04.013. [Epub ahead of print].


K. Lahmar-Belguendouz, H. Belguendouz, D. Hartani, O.S. Lahlou-Boukoffa, F. Bédiar-Boulaneb, C. Touil-Boukoffa. (2013). Effets du peroxynitrite dérivé du monoxyde d’azote sur des explants oculaires bovins en culture Original Research Article. Journal Français d’Ophtalmologie ; 36, 41-49.


Toumi, R., Abdelouhab, K., Rafa, H., Soufli, I., Raissi-Kerboua, D., Djeraba, Z., Touil-Boukoffa, C. (2013). Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis. (2013) Immunopharmacol Immunotoxicol ; 35(3):403-9.


Rafa, H., Saoula, H., Belkhelfa, M., Medjeber, O., Soufli, I., Toumi, R., de Launoit, Y., Moralès, O., Nakmouche, M., Delhem, N., Touil-Boukoffa C. IL-23/IL-17A Axis Correlates with the Nitric Oxide Pathway in Inflammatory Bowel Disease : Immunomodulatory Effect of Retinoic acid. (2013). J Interferon Cytokine Res ;37(3) 355-68.


Zeghir-Bouteldja R., Amri M., Bouaziz S., Mezioug D. & Touil-Boukoffa C. (2013). Comparativ e study of nitric oxide (NO) production during human hydatidosis : relationship w ith cystic fluid fertility. Parasitology Research ; 112(2) : 649-54.


Mesbah-Amroun H, Boukercha A, Bouzidi A, Saoula H, Nekmouche M, Roy M, Hugot JP, Touil-Boukoffa C, Polymorphismes du gène NOD2 chez des patients Algériens atteints de la maladie de Crohn, 2013.


Mesbah-Amroun H, Boukercha A, Saoula H, Nekmouche M, Touil-Boukoffa C (2013) “Maladie de Crohn et polymorphisme du gène NOD2 en Algérie” Ann Biol Clin ; 71, (1), 43-92. DOI : 10.1684/abc.2012.

ANNEE 2012

Bourouba M, Kariche N, Guiri N, Kraiba N, Zoubir H, Kheidri N, Graba A, Touil-Boukoffa C. High grade squamous intraepithelial lesions and cervical cancer associate with reduced plasmatic nitric oxide synthesis in Algerian patients with high-risk human papillomavirus. Tumor ecosystem in cancer progression and metastasis, Maison du séminaire, , 26-27 Novembre 2012, Nice, France.


M. Amri, C. Touil-Boukoffa. September 2012 ; P016 Impairment of TH1/TH17 host protective responses by macrophages alternative activation as a mechanism for helminthes survival Cytokine, Volume 59, Issue 3, Page 523.


H. Belguendouz, D. Messaoudene, L.M. Ahmedi, K. Lahmar, Z. Djeraba, D. Hakem, F. Otmani, D. Hartani, O.S. Lahlou-Boukoffa, C. Touil-Boukoffa. September 2012 ; P072 Arginine metabolism and IL-17 pathway in Behçet disease : A study in Algerian patients
Cytokine, Volume 59, Issue 3, Page 542.


M. Bourouba, A.-A. Zergoun, M. Elhadjan, F. Asselah, D. Djenaoui, C. Touil-Boukoffa. September 2012 ; P064 IL-12 expression in nasopharyngeal carcinoma tissues induces nitric oxide release but fail to induce anti-tumor activity Cytokine, Volume 59, Issue 3, Page 538.


M. Belkhelfa, H. Rafa, O. Medjeber, N. Behairi, M. Abada-Bendib, M. Makrelouf, S. Belarbi, A.N. Masmoudi, M. Tazir, C. Touil-Boukoffa. September 2012 ; P070 IL-17 and nitric oxide pathways are involved in inflammatory response during Alzheimer’s disease : A study in Algerian patients Cytokine, Volume 59, Issue 3,Page 541.


Ryma Toumi, Katia Abdelouhab, Hayet Rafa, Imene soufli, Chafia Touil-Boukoffa.23–26 September 2012, Potential therapeutic effect of probiotic on dextran sulfate sodium-induced colitis in mice : Assessment of nitric oxide production and mucus secretio. New Biotechnology, Volume 29, Supplement, Page S116.


Bourouba M, Boukercha A, Zergoun A, Zebboudj A, Elhadjan M, Djenaoui D, Asselah F, Touil-Boukoffa C.Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma..Biomarkers. 2012 Jul 21. [Epub ahead of print] .0788.


Djaballah-Ider F, Chaib S, Belguendouz H, Talbi D, Touil-Boukoffa C. T Cells Activation and Interferon-γ/Nitric Oxide Production during Behçet Disease : A Study in Algerian Patients. Ocul Immunol Inflamm. 2012 Jun ;20(3):215-7. Epub 2012 Apr 1.


Dalila Mezioug & Chafia Touil-boukoffa (2012). “Interleukin-17A correlates with interleukin-6 production in human cystic echinococcosis : a possible involvement of IL-17A in immunoprotection against Echinococcus granulosus infection”. Eur cytokine Netw, 23 (3), 112-9.


Razika Zeghir-bouteldja., Manel Amri., Samia Bouaziz., Dalila Mezioug & Chafia Touil-boukoffa (2012). Comparative study of nitric oxide (NO) production during human hydatidosis : relationship with cystic fluid fertility. Journal of Parasitology research.


Abdelouhab K, Rafa H, Toumi R, Bouaziz S, Medjeber O, Touil-Boukoffa C.. Mucosal intestinal alteration in experimental colitis correlates with nitric oxide production by peritoneal macrophages : Effect of probiotics and prebiotics. Immunopharmacol Immunotoxicol.2012.Aug ;34(4):590-7. Epub 2012 Jan 2.

ANNEE 2011

Messaoudene D, Belguendouz H, Ahmedi ML, Benabdekader T, Otmani F, Terahi M, Youinou P, Touil-Boukoffa C. Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet’s disease. J Inflamm (Lond). 2011 Nov 21 ;8(1):35. [Epub ahead of print].


Mehdi Bourouba, Ahmed-Amine Zergoun, Abderezak Zebboudj, Mohamed El-Hadjen, Chafia Touil-Boukoffa. (2011). Anti-TNF-alpha inhibits nitric oxide release in PBMC and primary tumor cultures from Algerian patients with nasopharyngeal carcinoma( Cytokines and Carcinogenesis). Cytokine 56, 40-42.


Hayet Rafa, Oussama Medjeber, Katia Abdelouhab, Mourad Belkhelfa, Houria Saoula,Ryma Zeriguine,M’hamed Nakmouche & Chafia Touil-Boukoffa.(2011). Involvement of CD23 overexpression in Inflammatory Bowel Disease Pathogenesis. Immunomodulatory effect of interleukine 10 and acid retinoic. Cytokine (Immunoregulation). 56, 39.


Manel Amri, Chafia Touil-Boukoffa.( 2011). Down-regulation of Th1/Th17 protective immune responses during human echinococcosis Cytokine (Immunopathology). 56, Issue 1, 88-89.


Amri M & Touil-Boukoffa C. (June 2011). Down regulation of Th2-allergic response by the helminth Echinococcus granulosus. Allergy and clinical immunology. Volume 66, Issue s94, pages 1–104. onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02604.


Rafa H, Medjeber O, Abdelouhab K, Belkhelfa M, Saoula H, Zeriguine R, Nakmouche M, Touil-boukoffa C. .(June 2011). Allergy and clinical immunology. Volume 66, Issue Supplement s94, pages 1–104. onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02604.


Arroul-Lammali A., Djeraba Z.,Belkhelfa M.,Belguendouz H., Hartani D.,Lahlou Boukoffa O.,Touil Boukoffa C (2011) Early involvement of Nitric Oxide in pathogenesis mechanisms of experimental autoimmune uveitis induced by Interphotoreceptor Retinoid-Binding Protein(IRBP), J Fr Ophtalmol. 2011 Oct 17. [Epub ahead of print].


Belguendouz H., Messaoudène D., Lahmar K., Ahmedi L., Medjeber O., Hartani D., Lahlou-Boukoffa O., Touil-Boukoffa C.Interferon-γ and Nitric Oxide Production During Behçet Uveitis : Immunomodulatory Effect of Interleukin-10. J Interferon Cytokine Res. 2011 Sep ;31(9):643-51.


Bourouba M., Benyelles-Boufennara A., Terki N., Kerboua-Baraka F E., Bouzid K., Touil-Boukoffa C. (2011). Epidermal growth factor receptor (EGFR) abundance correlates with p53 and Bcl-2 accumulation and patient’s age in a small cohort of North African nasopharyngeal carcinomas patients. European Cytokine Network. 1 ;22(1):38-44.


Rafa H, Medjeber O, Belkhelfa, Hakem D and Touil-Boukoffa C.(2011). Nitric Oxide Modulation by IFN-γ, IL-4, IL-10 and Anti-TNF-α in PBMC Cultures from Algerian Patients with Systemic Lupus Erythematosus Associated with Crohn’s Disease. Rheumatology Oxford Journal, Volume 50,IS2 ,Pp. ii14-ii21.

ANNEE 2010

Djeraba Z., Arroul-Lammali A., Medjeber O., Belguendouz H., Hartani D., Lahlou-Boukoffa O.S., Touil-Boukoffa C. (2010). Nitric oxide, biomarker of experimental autoimmune uveitis induced by S antigen. J Fr Ophtalmol. 2010 Dec ;33(10):693-700.


Rafa H., Abdelouaheb K., Belkhelfa M., Medjeber O., Saoula H.,Zeriguine R., Nakmouche M., Touil-Boukoffa C. (2010). Nitric oxide modulation by retinoic acid, IL-17A and TNF-α in PBMC and colonic mucosa cultures from Algerian patients with inflammatory bowel disease. Cytokine, 52 : 17-34.


Amri M & Touil-Boukoffa C. (2010). The parasite Echinoccocus granulosus promotes allergic response in human. Journal Comp.Blackwell Publishing Ltd. Allergy. Novel discoveries about the role of infectious in asthma and allergy, 65(S92),108.


Belguendouz H., Lahmar K., Ahmedi M L., Lahlou O S., Hartani D., Djennet H., Touil Boukoffa C. (2010). NOS/arginase balance modulation by IFNγ during Behcet disease. Cytokine, 52:17-34.


Rafa H., Amri M., Saoula H., Belkhelfa M. , Medjeber O., Boutaleb A S., Nakmouche A M., Touil-Boukoffa C. (2010). Involvement of Interferon-γ in Bowel Disease Pathogenesis by Nitric Oxide Pathway:A Study in Algerian Patients. Journal of Interferon & Cytokine Research, 30(9):691-697.

ANNEE 2009

Mézioug D. & Touil-Boukoffa C. (2009). Cytokine profile in human hydatidosis.Possible role in the immunosurveillance of patients infected with Echinococcocus granulosus. Parasite ,16:57-64.


Lahmar-Belguendouz K , Belguendouz H , Hartani D, O.S. Lahlou- Boukoffa O.S, Djeraba Z. Lammali A & C. Touil-Boukoffa C. (2009). Effets délétères des dérivés stables du monoxyde d’azote, marqueur inflammatoire des uvéites, sur les différentes tuniques de l’œil de bœuf en culture Journal français d’ophtalmologie.32 :247-256.


Amri M. ,Mezioug D., Touil-Boukoffa C (2009) . Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response. Involvement of IL-10 and IL-4 in evasion strategies of Echinococcus granulosus to host immune response. European Cytokine Network, 20(2):63-68.


Amri M., Mezioug D., Bouaziz S., Abdi Sofiane-Zaki & Touil-Boukoffa C. (2009). Modulation of nitric oxide production by Th1/Th2/Th17/Treg cytokines in culture of Echinococcus granulosus protoscolces : Possible presence of parasitic iNOS.Cytokine,48(1-2),75.


Belguendouz H., Messaoudene D., Ahmedi M.L., Lahmar K., Otmani F.,Hakem D& Touil-Boukoffa C.(2009).Inflammatory versus anti-Inflammatory IL-6 during Behcet Disease : Dual effect of Nitric Oxide and TGF-Beta. Cytokine,48(1-2), 96-97.


Rafa H., Belkhelfa M., Medjeber O., Bouaziz S., Djeraba Z., Lammali A., AbdelwahebK., Saoula H., Boutaleb A.F.,Nakmouche M & Touil-Boukoffa C. (2009). Nitric Oxide immunomodulation by IL-17 and Il-10 in Algerian patients with Inflammatory bowel Disease.Cytokine, 48(1-2),95.


Zeghir-bouteldja R., Amri M., Ait Aissa S., Bouaziz S., Mezioug D ., Touil-boukoffa C. (2009). “In vitro study of nitric oxide metabolites effects on human hydatid of Echinococcus granulosus,” Journal of Parasitology research.6204919,1-7.


H. Belguendouz, D. Messaoudene, K. Lahmar-Belguendouz, M.L. Ahmedi, O. Medjber,D. Hartani, F. Otmani, C. Touil-Boukoffa. (2009). CYTOKINES AND NITRIC OXIDE MODULATION DURING BEHÇET DISEASE.European Journal of Immunology,39(1-09).


H. Belguendouz, K. Lahmar- Belguendouz, M.L. Ahmedi, D. Messaoudene, O. Medjeber, C. Touil-Boukoffa.(2009).IN VITRO S ANTIGEN DELETERIOUS EFFECTS ON BOVINE OCULAR EXPLANTS : IMPLICATION OF NITRIC OXIDE. H. Belguendouz, K. Lahmar- Belguendouz, M.L. Ahmedi, D. Messaoudene, O. Medjeber, C. Touil-Boukoffa. European Journal of Immunology,39(1-09).


D. Mezioug, H. Belguendouz, C. Touil-Boukoffa .(2009).CONCOMITANT INVOLVMENT OF IL-6, RIL-6S AND STAT3 IN IMMUNE HOST RESPONSE DURING HUMAN ECHINOCOCCOSIS D. Mezioug, H. Belguendouz, C. Touil-Boukoffa .European Journal of Immunology,39(1-09)

ANNEE 2008

Jean-Luc Perfettini, Roberta Nardacci, Mehdi Bourouba, Frédéric Subra, Laurent Gros, Claire Séror, Gwenola Manic, Filippo Rosselli, Alessandra Amendola, Peggy Masdehors, Luciana Chessa, Giuseppe Novelli, David M. Ojcius, Jan Konrad Siwicki, Magdalena Chechlinska, Christian Auclair, José R. Regueiro, Hugues de Thé, Marie-Lise Gougeon, Mauro Piacentini, Guido Kroemer. PLoS ONE. 2008. Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia 3(6) : e2458. Published online 2008 June 18.


Belguendouz H., Messaoudene D., Hartani D., Chachoua L., Ahmedi M.L., Lahmar-Belguendouz K., Lahlou-Boukoffa O.S. & Touil-Boukoffa C. (2008). Effet de la corticothérapie sur la production des interleukines 8, 12 et du monoxyde d’azote au cours des uvéites « Behçet » et « idiopathique ». J.F.O. (Journal Français d’Ophtalmologie), 31 (4) :387-395.


Amri M., Mezioug D., Ait-Aissa S., Touil-Boukoffa C. (2008). In vivo IL-12 and IL-8 production in hydatic patients and their possible diffusion in hydatid cysts. European Cytokine Netw,19(3):23-29.


Belguendouz H., Messaoudene D., Ahmedi M.L., Lahmar K., Ider F.Z., Medjber O., Hartani D., Touil-Boukoffa C. (2008). IFNγ modulation by IL 18, IL 4 and IL 10 during BEHCET disease evolution. Cytokine, 43(3) : 257.


Belguendouz H., Messaoudene D., Ahmedi M.L., Lahmar K., Ider F.Z., Medjber O., Hartani D., Touil-Boukoffa C. (2008). IFNγ modulation by IL 18, IL 4 and IL 10 during BEHCET disease evolution, Medimond –International Proceedings,9-13.


Rafa H., Amri M., Belkhelfa M., Saoula H., Boutaleb A.F., Touil-Boukoffa C. (2008). Immunomodulatory production of NO by cytokines in algerian patients with bowel disease, Cytokine, 43 (3):256-257.


Rafa H., Amri M., Belkhelfa M., Saoula H., Boutaleb A.F., Touil-Boukoffa C. (2008). Immunomodulatory production of NO by cytokines in algerian patients with bowel disease,Medimont –International Proceedings ,87-90.


Amri M., Mezioug D., Bouaziz S., Touil-Boukoffa C. (2008). Echinococcus granulosus escape the TH1 protective response. Cytokine, 43 (3):300.

ANNEE 2007

H. Belguendouz, D. Messaoudene, K. Lahmar, D. Hartani, M.L. Ahmedi, C. Touil-Boukoffa (2007). IFN gamma modulation of nitric oxide production during active Behcet disease. Journal of Interferon & Cytokine Research 27 : 733.


Amri M., Mezioug D., Ait-Aissa S., Wietzerbin J. & Touil-Boukoffa C. (2007). Induction and Action of Interferon-gamma in human echinococcosis. Journal of Interferon & Cytokine Research 27 : 714.


Amri M., Aït Aïssa S., Belguendouz H., Mezioug D. & Touil-Boukoffa C. (2007). In Vitro Antihydatic Action of Gamma Interferon (IFN) is Dependent of Nitric Oxide (NO) pathway. Journal of Interferon & Cytokine Research, 22(9) : 781-787.

ANNEE 2006

Hartani D., Belguendouz H., Guenane H., Chachoua L., Lahlou-Boukoffa O.S. & Touil-Boukoffa C. (2006). Etude de l’effet des nitrites et des nitrates sur les rétines in vitro. J.F.O. (Journal Français d’Ophtalmologie), 29(1) : 32-36.


Aït Aïssa S., Amri M., Bouteldja R., Wietzerbin J. & Touil-Boukoffa C. (2006). Alteration in Interferon γ and Nitric oxide production in human echinococcosis : IFNγ and NO in anti-hydatic immune response. Bio. Cell. Mol. (Cellular and Molecular Biology), 52 : 65-70.


Guenane H., Hartani D., Chachoua L., Lahlou-Boukoffa O.S., Mazari S. & Touil-Boukoffa C. (2006). Production des cytokines Th1 /Th2 et du monoxyde d’azote au cours de l’uvéite Behcet et de l’uveite idiopathique : impact sur le pronostic des deux pathologies. J.F.O. (Journal Français d’Ophtalmologie), 29(2) : 146 – 152.

ANNEE 2005

Amri M., Wietzerbin J., Aït Aïssa S., Bouteldja R. & Touil-Boukoffa C. (2005). Nitric oxide- mediated anti-hydatic activity in human peripheral blood mononuclear cells induced by gamma interferon and the parasite itself. Cell Research, 15(10) : 272.


Belguendouz H., Hartani D., Messaoudène D., Guenane H. & Touil-Boukoffa C. (2005). Increased Levels of IL8, IL12, IL18 and Nitric Oxide in Behcet’s Disease. Correlation with Disease Activity. Cell Research, 15(10) : 240.

ANNEE 2004

Hartani D., Guenane H., Belguendouz H., Chachoua L., Lahlou-Boukoffa O.S. & Touil-Boukoffa C. (2004). Implication du monoxyde d’azote dans les désorganisations tissulaires lors des uvéites. J.F.O. (Journal Français d’Ophtalmologie), 1s : 244.

ANNEE 2002

Touil-Boukoffa, C., Mézioug D., Benblidia S. & Wietzerbin J. (2002). Th1 Cytokines are related to the induction of NOSynthase-2 in human liver echinococcosis. Journal of Interferon and Cytokine Research, 22 : 196-197.

ANNEE 2001

Touil-Boukoffa C., Mézioug D., Benblidia S. & Wietzerbin J. (2001). Cytokines and Nitric Oxide in the Immunology of Echinococcus granulosus Infection. Biotechnología Aplicada, 18 (Especial).

ANNEE 2000

Touil-Boukoffa C., Chabane N., Mézioug D., Benblidia S., Ardjoun M. & Wietzerbin J. (2000). Levels of IFN-γ, IL-12, IL-4 and IL10 are determined in sera and supernatants of PBMC Cultures from Hydatid Patients. European Cytokine Network, 11 : 286.

ANNEE 1999

Touil-Boukoffa C., Chabane N. & Wietzerbin J. (1999). Production of Interleukine-12 (IL-12) in Human Hydatidosis. Relationship between IFN-  production and IL-12 levels. Journal of Interferon & Cyokine Research, 19 : 155.

ANNEE 1998

Touil-Boukoffa C., Bauvois B., Sancéau J., Hamrioui B. & Wietzerbin J. (1998). Production of Nitrite Oxide (NO) in Human Hydatidosis. Relationship between Nitrite and IFN-γ levels. Biochimie, 80 : 739-744.

ANNEE 1997

Touil-Boukoffa C., Sanceau J., Bauvois B., Hamrioui B. & Wietzerbin J. (1997). Production of Interferon-gamma and Nitric oxide (NO) by peripheral Leukocytes from Hydatid patients. Journal of interferon & cytokine research, 17(2) : 113.


Touil-Boukoffa C., Sanceau J., Tayebi B., Wietzerbin J. (1997). Relationship Among Circulating Interferon. Tumor necrosis factor-α and Interleukine-6 and serological reaction against parasitic Antigen in human hydatidosis. Journal of Interferon & Cytokine Research, 17(4) : 211-217.

ANNEE 1996

Touil-Boukoffa C., Sanceau J., Bauvois B., Wietzerbin J. (1996). Presence of nitrite in sera of patients with hydatidose correlates with Circulating Cytokine levels. Eur. Cytok. Netw., 7(3) : 505.

ANNEE 1995

Touil-Boukoffa C., Wietzerbin J., Sanceau J. & Tayebi B. (1995). Interferon, Tumor necrosis factor-α and interleukin-6 production correlate with immunoreactivity against Parasitic Antigen in human hydatic disease. Journal of Interferon & Cytokine Research, 15 : 206.